Single-Use Centrifuges
Benefits of Single-Use Systems
Optimize Product Recovery and Scalability
Since 2009, CARR Biosystems has been providing single-use separation systems to biopharma companies seeking low-shear separation, high-recovery performance, and fast processing time. Avoid the expense and waste of CIP/SIP stainless steel centrifuges and step up to the scalable, industry-leading, UniFuge platform.
More Data in Less Time
- Get more data in less time while lowering costs. Our smallest scale UniFuge technology - UFMicro - requires minimal cell culture volume and technician time.
- Optimize your process performance when developing process CTQs with low-shear separation and remarkably high processing speed.
Scale-up Seamlessly with UniFuge
- De-risk Process Scaling: Establish easily transferable CTQs as you pass clinical milestones.
- Optimize product quality via tunable process settings (flow, force).
- Processing volumes to support you from process development to commercial manufacturing:
| UFMicro | UFMini | Pilot Shallow | Pilot Standard | U2K | |
|---|---|---|---|---|---|
| Min Proc Vol | 70 ml | 270 ml | 1 L | 1.8 L | 10 L |
| Max Proc Vol | 25 L | 25 L | 500 L | 500 L | 2000+ L |
Unsurpassed Performance
- Optimize separation performance with best-in-class low-shear separation ensuring:
- High cell viability for cell therapy and cellular agriculture applications
- Isolation of antibodies from cell culture supernatant
- Reduction of BSA levels well below the required minimum
- Achieve high processing speeds without sacrificing the separation efficiency needed for demanding applications
With a small footprint, UniFuge systems are easy to operate, simplify training and require fewer staff than traditional centrifuges.
- 100% closed system
- Low shear
- Clear center
- Reduce filtration needs by 85%
- Set up and change over within 15 min
- Cell viability up to 98%
- Yield up to 98%
- Confidently scale up to the U2k® or scale down to the UFMini®
- Variable speed up to 4,000 x g
- Reduce HCP and other contaminants
- GMP-compliant data trail 21cfrPart11
- Extractables data available
Publications
Want to learn more about the performance of single-use centrifuges from CARR Biosystems? Review whitepapers, case studies, and more here.
Key Features
Advantages of Single-Use Centrifuges
Easy-to-use, reliable equipment that delivers high product recovery.
Performance
Our proven low-shear technology boasts up to 98% yield and 98% or higher typical cell viability.
Scalability
Our equipment can be used from development to commercial licensure and across different reactor volumes.
Ease of Use
Our machines are rapid to install and simple to operate.
Small Footprint
Our single-use centrifuges have a small footprint.
The UniFuge Family
Our Single-Use Centrifuges
The scalable UniFuge family of centrifuges has a variable g-force up to 4,000 x g. They employ gamma-irradiated sterile single-use modules, reducing the risk of contamination.
Endorsements
See What People Are Saying About Our Equipment
“The U2k was fairly simple to use and scales nicely from the UFMini and UniFuge.”
Cell Therapies Bioproduction Expert
“This really opens the door with the potential to go above 300 L.”
mRNA and pDNA Bioproduction Expert
“The 20L/min flow rate is great for harvesting from 1,000-2,000 L+ bioreactors. Processing ~1,000 L/hr is very helpful for our operators. It would save a significant amount of time.”
mAb Bioproduction Expert
“The UniFuge line is easy to scale-up to the U2k or down to the UFMini.”
mAbs Bioproduction Expert
“The UniFuge was fairly simple to use and scaled nicely from the UFMini.”
Cell Therapies Bioproduction Expert
“The UniFuge has higher g forces and flow rates [compared to competitive offerings].”
Viral Vector Bioproduction Expert, HEK
“The UniFuge had the shortest processing time versus Ksep.”
Protein Separation Bioproduction Expert, CHO
"The UniFuge is scalable, easier to operate, and my process yield is better than using depth filters."
Protein Separation Bioproduction Expert, CHO
"This one is perfect. This would reduce our harvest time significantly. I think it fits well into the needs for a Phase III trial."
Cell Therapy Bioproduction Expert
“[The UniFuge line] is scalable, easier to operate, and my process yield is better than using depth filters.”
Protein Separation Bioproduction Expert, CHO
“The UniFuge had the shortest processing time versus Ksep.”
Protein Separation Bioproduction Expert, CHO
“The UniFuge line is simpler and required less calibration than other solutions we have tried.”
Protein Separation Bioproduction Expert, CHO
“The UniFuge was easy to scale-up, and the Viafuge enables us to recover viable cells at large scale, beyond what single-use can typically accomplish."
Cellular Agriculture Entrepreneur
“My biggest reason to avoid centrifuges has been that they don’t scale down, so process development is hard, and clean-in-place is a pain. [UniFuge] neatly addresses both.”
Viral Vector Gene Therapy Bioproduction Expert
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